PUBLICATIONS
Visualizing PIEZO1 Localization and Activity in hiPSC-Derived Single Cells and Organoids with HaloTag Technology
Bertaccini GA, Casanellas I, Evans EL, Nourse JL, Dickinson GD, Liu G, Seal S, Ly AT, Holt JR, Wijerathne TD, Yan S, Hui EE, Lacroix JJ, Panicker MM, Upadhyayula S, Parker I, Pathak MM.
bioRxiv (2024)
Single-particle tracking reveals heterogeneous PIEZO1 diffusion
Ly AT*, Freites JA*, Bertaccini GA, Evans EL, Dickinson GD, Tobias DJ, Pathak MM.
bioRxiv (2024)
Piezo1-mediated mechanotransduction enhances macrophage oxLDL uptake and atherogenesis.
Atcha H, Kulkarni D, Meli V, Veerasubramanian P, Cahalan M, Pathak MM, Liu W.
PNAS Nexus, pgae436 (2024).
doi.org/10.1093/pnasnexus/pgae436 PDF
PIEZO1 regulates leader cell formation and cellular coordination during collective keratinocyte migration
Chen J*, Holt JR*, Evans EL, Lowengrub JS†, Pathak MM†
PLoS Comput Biology. 2024 Apr 5;20(4):e1011855 (2024). PDF bioRxiv
Membrane curvature governs the distribution of Piezo1 in live cell
Yang S, Miao X, Arnold S, Li B, Ly AT, Wang H, Wang M, Pathak MM, Zhao W, Cox CD, Shi Z
Nature Communications, 13(7467) (2022)
doi: 10.1038/s41467-023-36108-9 PDF
Piezo1 regulates cholesterol biosynthesis to influence neural stem cell fate during brain development
Nourse JL, Leung V, Abuwarda H, Evans EL, Izquierdo-Ortiz E, Ly A, Truong N, Smith S, Bhavsar H, Bertaccini G, Monuki E, Panicker MM, and Pathak MM
Journal of General Physiology, 154(10): e202213084. (2022)
doi: 10.1085/jgp.202213084 PDF
News article here
Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing
Holt, J. R., Zeng, W.-Z.*, Evans, E. L.,* Woo, S.-H.*, Ma, S., Abuwarda, H., Loud, M., Patapoutian, A.†, Pathak, M. M.†
eLife 2021;10:e65415 (2021)
doi: 10.7554/eLife.65415 PDF
News article here
Crosstalk Between CD11b and Piezo1 Mediates Macrophage Responses to Mechanical Cues
Atcha, H., Meli, V. S., Davis, C. T., Brumm, K. T., Anis, S., Chin, J., & Jiang, K., Pathak M. M., Liu W. F.
Frontiers in immunology, 12. (2021)
doi: 10.3389/fimmu.2021.689397 PDF
Ion channel mediated mechanotransduction in immune cells
Atcha, H., Jairaman, A., Evans, E. L., Pathak, M. M., Cahalan, M. D., & Liu, W. F.
Current Opinion in Solid State and Materials Science, 25(6), 100951. (2021)
doi: doi.org/10.1016/j.cossms.2021.100951 PDF
Piezo1 channels restrain regulatory T cell polarization but are dispensable for effector CD4+ T cell responses
Jairaman A*, Othy S*, Dynes JL, Yeromin AV, Zavala A, Greenberg ML, Nourse JL, Holt JR, Cahalan SM, Parker I, Pathak MM, and Cahalan MD
Science Advances, 7(28). (2021)
doi: 10.1126/sciadv.abg5859 PDF
Mechanically-activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing
Atcha H, Jairaman A, Holt JR, Meli VS, Nagalla RR, Veerasubramanian PK, Brumm KT, Lim HE, Cahalan MD, Pathak MM, and Liu WF
Nature Communications, 12(1), 1-14. (2021)
doi: 10.1038/s41467-021-23482-5 PDF
Mechanobiology of neural development
Abuwarda H, Pathak MM
Current Opinion in Cell Biology, 66:104-111 (2020)
doi: 10.1016/j.ceb.2020.05.012 PDF
Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers
Ellefsen K*, Holt JR*, Chang A*, Nourse JL*, Arulmoli J, Mekhdijan A, Abuwarda H, Flanagan LA, Dunn AR, Parker I, Pathak MM
Communications Biology 2, Article number: 298 (2019)
doi: 10.1038/s42003-019-0514-3 PDF
Mechanosensitive Ion Channel Piezo1 Regulates Diet-Induced Adipose Inflammation and Systemic Insulin Resistance
Zhao C, Sun Q, Tang L, Cao Y, Nourse JL, Pathak MM, Lu X, Yang Q
Front Endocrinol (Lausanne). 10:373. (2019)
doi: 10.3389/fendo.2019.00373 PDF
How cells channels their stress: Interplay between Piezo1 and the Cytoskeleton.
Nourse JL, Pathak MM.
Seminars in Cell and Development Biology. 71:3-12. (2017). PDF
The Hv1 proton channel responds to mechanical stimuli.
Pathak MM*, Tran T*, Hong L, Morris CE, Tombola F.
Journal of General Physiology. 148(5):405-418. (2016). PDF
Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering.
Arulmoli J, Wright HJ, Phan Duc TT, Sheth U, Que RA, Botten GA, Keating M, Botvinick EL, Pathak Medha M, Zarembinski TI, Yanni DS, Razorenova OV, Hughes CCW, Flanagan LA.
Acta Biomaterialia. 43:122-38. (2016). PDF
Reflectin as a Material for Neural Stem Cell Growth.
Phan L*, Kautz R*, Arulmoli J, Kim I, Le DT, Shenk MA, Pathak MM†, Flanagan LA†, Tombola F†, Gorodetsky AA†.
ACS Applied Materials & Interfaces. 13;8(1):278-84. (2016). PDF
Before 2016
Static stretch affects neural stem cell differentiation in an extracellular matrix-dependent manner.
Arulmoli J, Pathak MM, McDonnell LP, Nourse JL, Tombola F, Earthman JC, Flanagan LA.
Scientific Reports. 5:8499. (2015). PDF
Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells.
Pathak MM†, Nourse JL, Tran T, Hwe J, Arulmoli J, Le DTT, Bernardis E, Flanagan LA, Tombola F†.
Proceedings of the National Academy of Sciences. 111(45):16148-53. (2014). PDF
Evidence for functional diversity between the voltage-gated proton channel Hv1 and its closest related protein HVRP1.
Kim IH, Hevezi P, Varga C, Pathak MM, Hong L, Ta D, Tran CT, Zlotnik A, Soltesz I, Tombola F.
PLoS One. 9(8):e105926. (2014). PDF
Membrane biophysics define neuron and astrocyte progenitors in the neural lineage.
Nourse JL*, Prieto JL*, Dickson AR, Lu J, Pathak MM, Tombola F, Demetriou M, Lee AP, Flanagan LA.
Stem Cells. 32(3):706-16. (2014). PDF
Voltage-sensing domain of voltage-gated proton channel Hv1 shares mechanism of block with pore domains.
Hong L, Pathak MM, Kim IH, Ta D, Tombola F.
Neuron. 77(2):274-87. (2013).
Commentary: Kalia & Schwartz. Common principles of voltage-dependent gating for Hv and Kv channels.
Neuron. 77(2):214-6. (2013). PDF
Closing in on the resting state of the Shaker K+ channel.
Pathak MM*, Yarov-Yarovoy V*, Roux B, Agarwal G, Kohout S, Barth P, Tombola F, Isacoff EY.
Neuron. 56(1):124-40. (2007). PDF
The twisted ion-permeation pathway of a resting voltage-sensing domain.
Tombola F, Pathak MM, Gorostiza P, Isacoff EY.
Nature. 445(7127):546-9. (2007). PDF
How does voltage open an ion channel?
Tombola F, Pathak MM, Isacoff EY.
Annual Review of Cell and Developmental Biology. 22:23-52. (2006). PDF
How far will you go to sense voltage?
Tombola F, Pathak MM, Isacoff EY.
Neuron. 48:719-25. (2005). PDF
Voltage-sensing arginines in a potassium channel permeate and occlude cation-selective pores.
Tombola F, Pathak MM, Isacoff EY.
Neuron. 45:379-88. (2005). PDF
The cooperative voltage sensor motion that gates a potassium channel.
Pathak MM, Kurtz L, Tombola F, Isacoff EY.
Journal of General Physiology. 125:57-69. (2005). PDF
* Denotes Equal Contribution
† Corresponding authors.